%0 Journal Article
%T A 3D Convolutional Neural Network Framework for Alzheimer's Disease Diagnosis Based on Domain-Specific Transfer Learning and Classifier Chains
%A Mikko Lahtinen
%A Elina Salo
%A Juhani Virtanen
%J Journal of Medical Sciences and Interdisciplinary Research
%@ 3108-4826
%D 2024
%V 4
%N 2
%R 10.51847/mIQmYtQCjy
%P 147-155
%X This work explores diverse architectures for deep convolutional neural networks (CNNs). It analyzes the influence of domain-specific transfer learning on distinguishing between patients with Alzheimer’s Disease (AD), Mild Cognitive Impairment (MCI), and cognitively normal (CN) subjects. Training relied on 1118 3D FDG-PET brain scans acquired through the ADNI initiative. We developed standalone binary classifiers, a multiclass model, and two different chains composed of binary classifiers for sequential multiclass decision-making. Chain A started by separating cognitively normal (CN) individuals from all non-CN cases, then distinguished Alzheimer’s disease (AD) from mild cognitive impairment (MCI). Chain B reversed the initial step, first identifying AD against non-AD subjects before classifying MCI versus CN. Every classifier variant was trained from scratch and with domain-specific transfer learning initialized from Med3D weights. All configurations matched or approached current state-of-the-art levels. Chain A stood out, recording 96% accuracy, 95% F1 score, and 99% AUROC. In contrast, domain-specific transfer learning often degraded performance across most models, reducing accuracy by up to 55%. Overall, the study underscores the value of binary classifier chains while prompting reconsideration of domain-specific transfer learning practices.
%U https://smerpub.com/article/a-3d-convolutional-neural-network-framework-for-alzheimers-disease-diagnosis-based-on-domain-specif-jkpezknrnwo5eyo