Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is an uncommon form of Hodgkin lymphoma (HL) that is characterized by its distinct morphology, typically affects older individuals, and has a lower incidence of mediastinal involvement. It is also associated with a higher relapse rate and a better prognosis compared to classical Hodgkin lymphoma (CHL). Unlike CHL, the tumor cells in NLPHL, known as LP cells, usually retain a B cell phenotype and do not express CD30. Due to the rarity of this subtype, limited research is available. In this study, we present a series of 10 cases of NLPHL diagnosed at our institution over a span of 10 years. The cases were retrospectively analyzed and classified based on morphological features and immunophenotypic patterns. Prognostic factors were also investigated. Our findings showed a predominance of peripheral lymph node involvement and generally favorable outcomes. In addition, two unusual cases were identified: one involving NLPHL associated with Rosai-Dorfman disease (RDD) and the other a composite lymphoma containing both NLPHL and diffuse large B cell lymphoma (DLBCL) components.
