Obesity has now become a global concern and contributes to various risk factors, especially in Western countries, where its prevalence has increased sharply. This surge has led to a significant increase in cardiovascular diseases in the general population. Inflammatory proteins, such as C-reactive protein (CRP), play an important role in the acute phase response to inflammation. This study aimed to investigate the impact of obesity on inflammation, as measured by CRP levels, in obese patients who exhibit frequent inflammatory responses. These patients may be at an elevated risk of contracting COVID-19 due to the effects of obesity on the immune system, with variations observed based on gender, ethnicity, and age. Our findings emphasize the importance of obese individuals maintaining low CRP levels to mitigate the risk of COVID-19 infection.