%0 Journal Article
%T Gender-Based Disparities in Chronic Kidney Disease: Insights from a Dual-Center Study in Nigeria
%A Peter Kehinde Uduagbamen
%A Abdallah Olukayode AdebolaYusuf
%A Sule Ilegieuno Ahmed
%A Mary Umoh Thompson
%A Boladale Ajani Alalade
%A Marion Itohan Ogunmola
%A Tolulope Esther Falana
%A Olutomiwa Ayoola Omokore
%A Chibuike Christian Emmanuel
%J International Journal of Social and Psychological Aspects of Healthcare
%@ 3108-4818
%D 2022
%V 2
%N 1
%R 10.51847/V9S94I0APL
%P 57-67
%X There are well-documented gender differences in both the physiological and pathological aspects of various health conditions, including kidney disease. These differences must be understood to improve strategies for the prevention and treatment of kidney diseases. In this study, we examined the risk factors, epidemiological trends, clinical and radiological findings, laboratory results, and responses to pharmacological treatment in CKD patients in Nigeria, focusing on gender-based differences. A study was conducted with 144 individuals diagnosed with chronic kidney disease, ranging from stage 3 to non-dialytic stage 5. Participants underwent blood, urine, and radiological tests to assess albuminuria, kidney function, and size. Results were analyzed by gender, with 82 male and 62 female participants. The mean age of males was 47.9 ± 16.8 years, and for females was 50.5 ± 14.73 years. The study showed that a higher proportion of participants aged 65 years and above were females. Chronic interstitial nephritis was more common in women, whereas men were more likely to have chronic glomerulonephritis. Women were also more prone to metabolic acidosis, hyponatremia, and hyperphosphatemia. In contrast, men were more frequently treated with vitamin D analogs and erythropoietin, while women tended to use sodium bicarbonate and phosphate binders more often. Certain factors such as increasing age (OR-3.28, CI-2.69-3.87), hyponatremia (OR-4.74, CI-2.10-6.33), hypoalbuminemia (OR-4.56, CI-3.45-7.49), and metabolic acidosis (OR-4.14, CI-1.46-4.92) were more strongly associated with females. Gender differences were evident in the epidemiology, laboratory findings, and response to treatments in patients with chronic kidney disease. Women had higher levels of hyponatremia and hyperphosphatemia, while men showed higher albumin levels and larger kidney sizes. Gender-based median range cut-offs for several clinical parameters would improve prevention, treatment, and follow-up care for individuals with chronic kidney disease.
%U https://smerpub.com/article/gender-based-disparities-in-chronic-kidney-disease-insights-from-a-dual-center-study-in-nigeria-8drcqd2vemwqss3