TY  - JOUR
T1  - Influence of OASL on Oxaliplatin-Triggered Immunogenic Cell Death in Gastric Cancer Through the cGAS-STING Signaling Pathway
A1  - Laura Katherine Mitchell
A1  - Hannah Olivia Brooks
A1  - David Andrew Collins
A1  - Peter Jonathan Moore
A1  - Samuel Edward Wright
A1  - Oliver Thomas Green
JF  - Archive of International Journal of Cancer and Allied Science
JO  - Arch Int J Cancer Allied Sci
SN  - 3108-4834
Y1  - 2021
VL  - 1
IS  - 1
DO  - 10.51847/nr4Epz4CW0
SP  - 103
EP  - 118
N2  - This study explores the regulatory role of 2'-5' oligoadenylate synthetase-like (OASL) in modulating oxaliplatin (OXA)-induced immunogenic cell death (ICD) in gastric cancer (GC) via the cGAS-STING signaling pathway. Silencing OASL resulted in increased ICD expression, whereas its overexpression suppressed these effects. Transcriptomic profiling of OASL-knockdown and control GC cells treated with OXA demonstrated marked enrichment in the cGAMP-mediated second messenger pathway. As a key upstream enzyme, cGAS generates the second messenger cGAMP, which directly activates STING. Mechanistic investigations confirmed that OASL regulates OXA-induced ICD in GC cells through the cGAS-STING pathway. Co-immunoprecipitation and immunofluorescence assays revealed a direct interaction between OASL and cGAS proteins. These findings were further corroborated in an in vivo mouse model. Collectively, the data indicate that OASL modulates OXA-induced ICD via cGAS-STING, influencing chemosensitivity, and highlight OASL as a potential target for enhancing OXA efficacy in GC treatment.
UR  - https://smerpub.com/article/influence-of-oasl-on-oxaliplatin-triggered-immunogenic-cell-death-in-gastric-cancer-through-the-cgas-wtrxi0uaczjxhv7
ER  -