Undifferentiated connective tissue dysplasia (UCTD) is a hereditary disorder that typically manifests its clinical features in early childhood, particularly within the first five years of life. One common complication of UCTD is vegetative-vascular dystonia, which is linked to structural abnormalities in collagen. These changes can trigger a range of symptoms, including heightened psycho-emotional distress, especially in children who exhibit anxiety as a primary feature. This study explored the effectiveness of an integrative art-based therapeutic approach, specifically fairytale therapy, in managing psychosomatic disturbances in children with UCTD. After a six-month intervention, children participating in the art therapy program demonstrated a statistically significant reduction in psycho-emotional stress, averaging 13.2 ± 0.5 points (P < 0.05). Skin-galvanic response (SGR) outcomes also differed between groups: while classical psychotherapy produced a slight, non-significant increase (6.9 ± 0.01 units, P > 0.05), the integrative art therapy group showed a significantly greater improvement (8.6 ± 0.01 units, P < 0.05). These results indicate that fairytale-based integrative art therapy can be an effective method for alleviating anxiety and emotional tension in children with UCTD.