The clinical homecare sector has become increasingly associated with high-cost injectable (parenteral) drug treatments and is expanding rapidly in the United Kingdom, with an annual growth rate of 20%. It is predicted that this could increase to 60% if all medications suitable for home care were included. Recent figures indicate the continued growth of homecare medicines services, which now serve over 500,000 patients, with expenditures reaching £3.2 billion in 2021. Given the substantial spending by the National Health Service (NHS) and the large patient population, it is important to examine the experiences, opinions, and perspectives of both patients and healthcare professionals (HCPs) regarding this therapy. This review seeks to examine the experience of home parenteral therapy (HPT) through qualitative research approaches. By expanding on existing quantitative research, the aim is to gain a deeper understanding of the topic. As highlighted in this review, homecare offers potential benefits, such as cost savings and enhanced patient experience. However, several challenges have been observed globally. Key factors for successful homecare implementation include patient education, support, training, ongoing supervision, and HCPs' competencies in managing patients. These elements play a critical role in determining whether the self-administration of parenteral therapy at home is successful and may significantly impact treatment adherence and outcomes. This area requires urgent research.