TY  - JOUR
T1  - Liver Transplantation in the Management of Colorectal Cancer with Liver Metastases
A1  - Maria Fernanda Sanchez
A1  - Gabriela Lucía Perez
JF  - Archive of International Journal of Cancer and Allied Science
JO  - Arch Int J Cancer Allied Sci
SN  - 3108-4834
Y1  - 2022
VL  - 2
IS  - 1
DO  - 10.51847/8j287tzdnO
SP  - 49
EP  - 64
N2  - Over the past ten years, accumulating evidence from several clinical investigations has shown that liver transplantation offers a meaningful survival advantage for selected patients with colorectal cancer and liver metastases. In parallel, progress in donor organ preservation techniques has increased the available donor pool, thereby enabling consideration of broader indications for liver transplantation, including patients with unresectable colorectal cancer liver metastases. Current evidence indicates that overall survival (OS) following liver transplantation in this population is comparable to outcomes observed in standard liver transplant recipients. On the basis of these findings, organ allocation policies in the United States are evolving to permit the use of deceased donor livers for carefully selected patients with unresectable colorectal cancer liver metastases. Published studies consistently highlight improved outcomes among patients who undergo complete (R0) resection of the primary tumor, receive 6–12 months of systemic chemotherapy before transplantation, and undergo meticulous radiologic reassessment—often incorporating positron emission tomography/computed tomography—to exclude extrahepatic disease. Tumor responsiveness to pretransplant chemotherapy is a critical determinant of long-term benefit, whereas disease progression during chemotherapy is generally regarded as a contraindication to transplantation. Favorable prognostic indicators reported in the literature include a carcinoembryonic antigen level ≤80 µg/L and a maximum liver lesion diameter 
UR  - https://smerpub.com/article/liver-transplantation-in-the-management-of-colorectal-cancer-with-liver-metastases-kb1hgxzvlb1wnio
ER  -