Multidetector computed tomography (MDCT) has emerged as a promising non-invasive imaging technique for assessing vascular anatomy and characterizing atherosclerotic plaque morphology across various arterial regions. MDCT allows for comprehensive assessment of the entire arterial system and enables visualization of the vessel wall, including quantification of both calcified and non-calcified plaques. This study aimed to evaluate the morphological characterization of atherosclerotic plaques in coronary artery disease using MDCT in patients clinically diagnosed with ischemic heart disease (IHD). This study included 72 patients (56.9% male, 43.1% female), aged between 46 and 80 years, who were scanned using a 64-slice MDCT scanner (TOSHIBA Aquilion system). All scans were performed in the axial plane at the Radiology Department of Royal Care International Hospital (RCIH), Khartoum, Sudan, between March 2014 and May 2016. Post-processing was performed using Vetrea software to obtain multiplanar reconstructions (MPR) and three-dimensional images. Analysis of the CT scans revealed calcified plaque in 19.4% of cases in the right coronary artery (RCA), 16.7% in the left anterior descending artery (LAD), and 13.9% in the left circumflex artery (LCx). The findings indicate that 64-slice MDCT is an effective modality for identifying and differentiating between calcified and non-calcified coronary artery plaques.