TY  - JOUR
T1  - Thrombotic Impact on Muscle Tissue: Histological Insights in Gastrointestinal Cancer Cases
A1  - Petro Bodnar
A1  - Yaroslav Bodnar
A1  - Tetiana Bodnar
A1  - Yurii Soroka
A1  - Bodnar Liudmyla
JF  - Journal of Medical Sciences and Interdisciplinary Research
JO  - J Med Sci Interdiscip Res
SN  - 3108-4826
Y1  - 2021
VL  - 1
IS  - 1
DO  - 10.51847/8DEdL1ZXlu
SP  - 45
EP  - 49
N2  - A frequent complication observed in cancer patients is thrombosis, which affects both arterial and venous circulation. However, the exact mechanisms of blood clot formation and the development of disseminated intravascular coagulation (DIC) remain unclear. This study performed a morpho-histological examination of the lower limb muscles in two groups of cancer patients who also experienced deep vein thrombosis leading to thrombus migration. In both groups, which succumbed to pulmonary embolism following clot migration from the lower limb veins, significant dystrophic changes in muscle fibers were identified. These changes were accompanied by the narrowing of the arteries and significant dilation of the venous vessels. In addition, endothelial damage was evident in all venous vessels examined, indicating the presence of thrombosis in the veins responsible for draining blood from the muscle tissue. Patients with pancreatic and/or colorectal cancer showed substantial hemodynamic, hypertrophic, dystrophic, and atrophic modifications in muscle fibers. The findings indicate a systemic impact of malignancies on vascular function and hemodynamics in the lower extremities.
UR  - https://smerpub.com/article/thrombotic-impact-on-muscle-tissue-histological-insights-in-gastrointestinal-cancer-cases-p8gmxnwqhurbjjw
ER  -