This study aimed to investigate the relationship between self-medication practices, attitudes toward medical services, and personal characteristics. The study included 1,068 participants from Romania. Data was collected using a questionnaire that included questions about the participant's residence, age, gender, level of education, satisfaction with doctors, and self-medication practices. The relationship between these variables was evaluated using the Crosstab-Chi Square test. The findings show a significant relationship between personal characteristics—such as age, gender, education, and residence—and the practice of self-medication. The study emphasizes the importance of considering these personal factors in health education and policies regarding self-medication, as they influence health-related decisions. By analyzing the influence of personality traits, we could predict medical behaviors in different contexts. Understanding the reasons behind the public’s skepticism or reluctance toward medical services can help improve future healthcare campaigns.