Written by Rosa Coppola
Published in Vol 1 Issue 1, 2021
Advancements in targeted therapy have significantly influenced modern cancer treatment. Among these, epidermal growth factor receptor (EGFR) inhibitors are widely utilized for managing metastatic, recurrent, and advanced malignancies. This report discusses a 74-year-old male diagnosed with metastatic colorectal cancer who experienced symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) alongside an acneiform eruption during cetuximab therapy in combination with FOLFOX chemothe
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Written by Gaye Keser
Published in Vol 1 Issue 1, 2021
This study aimed to assess the level of oral cancer awareness among medical professionals in Turkey. This study included 90 medical doctors who were provided with a 25-item questionnaire. These questions assessed their knowledge of oral cancer risk factors, screening methods, attitudes toward oral cancer, management of oral care, and general cancer awareness of the disease. All respondents identified cigarette use and viral infections as risk factors, with 95.6% also confirming alcohol consumpti
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Written by Harishankar Mahto
Published in Vol 1 Issue 1, 2021
Chronic inflammation is a key factor in the development of colorectal cancer (CRC). Lymphotoxin-alpha (LT-α), a multifunctional pro-inflammatory cytokine, has shown both tumor-promoting and tumor-suppressing properties. The relationship between the intronic LT-α +252A/G single-nucleotide polymorphism (SNP) and various cancers, including CRC, has been widely studied with inconsistent findings. This study investigated the association between the LT-α +252A/G SNP and CRC susceptibility in the Kashm
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Written by Jay Hoover
Published in Vol 1 Issue 1, 2021
In recent years, the consumption of vitamin and mineral supplements (VMS) has increased in various patient groups, especially among people with cancer. This study aims to assess and compare the awareness and attitudes toward VMS among healthy individuals and cancer patients. A structured questionnaire was distributed to both cancer patients and a healthy control group collecting information about their sociodemographic profiles, knowledge, and perspectives regarding VMS use. Among the 778 respon
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Written by Cristina Secosan
Published in Vol 1 Issue 1, 2021
Minimal deviation adenocarcinoma (MDA) of the cervix is a highly differentiated form of adenocarcinoma that presents a significant diagnostic challenge. Due to its subtle microscopic features, MDA is often mistaken for benign conditions, which confuses pathologists and complicates its diagnosis in gynecological oncology. This leads to frequent misinterpretation and some cases are mistakenly diagnosed as benign, leading to inappropriate management. Both false-positive and false-negative MDA diagn
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Written by Vanessa M. LópezOzuna
Published in Vol 1 Issue 1, 2021
Water-pipe smoking (WPS), a common form of tobacco use, is particularly prevalent among young women in the Middle East. The smoke produced by WPS contains harmful substances similar to those found in cigarettes and is often associated with an increased risk of various cancers, including breast cancer. However, the specific genes affected by WPS and the mechanisms driving cancer initiation and progression, particularly in breast cancer, remain largely unknown. This study investigated the effects
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Written by Kenji Hiroto Sakamoto
Published in Vol 1 Issue 1, 2021
Endometrial cancer (EC) is a gynecologic malignancy closely associated with disruptions in metabolic processes. A majority of EC patients respond poorly to immunotherapy, highlighting the urgent need to identify novel therapeutic targets at the interface of metabolism and immune regulation. In vitro, a combination of proteomics, CUT&Tag (cleavage under targets and tagmentation) sequencing, dual-luciferase reporter assays, lipidomic profiling, and macrophage–tumor co-culture systems was employed
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Written by Emily Rose Carter
Published in Vol 1 Issue 1, 2021
Despite widespread clinical use of antibodies targeting programmed cell death-1 (PD-1) and programmed cell death ligand 1 (PD-L1), dependable biomarkers for anticipating immune-related adverse events (irAEs) remain largely unavailable. This investigation examined whether inherited variation within the PD-1 gene could identify patients at increased risk of irAEs following immune checkpoint blockade and clarified the molecular mechanism through which the most relevant variant exerts its biological
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Written by Laura Katherine Mitchell
Published in Vol 1 Issue 1, 2021
This study explores the regulatory role of 2'-5' oligoadenylate synthetase-like (OASL) in modulating oxaliplatin (OXA)-induced immunogenic cell death (ICD) in gastric cancer (GC) via the cGAS-STING signaling pathway. Silencing OASL resulted in increased ICD expression, whereas its overexpression suppressed these effects. Transcriptomic profiling of OASL-knockdown and control GC cells treated with OXA demonstrated marked enrichment in the cGAMP-mediated second messenger pathway. As a key
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Written by Helena Sofia Martins
Published in Vol 1 Issue 1, 2021
Improving the activity of chimeric antigen receptor T (CAR-T) cell therapy in solid cancers represents a critical unmet need in oncology. Because nuclear factor of activated T cells (NFAT) signaling governs multiple aspects of T cell behavior, we proposed that selective control of NFAT activity via inhibition of c-Jun N-terminal kinases (JNK) could reprogram CAR-T cells toward superior tumor-eliminating capacity. A lentiviral system encoding short-hairpin RNA was established to achieve durable J
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Written by Mateusz Piotr Kowalczyk
Published in Vol 1 Issue 1, 2021
Therapeutic strategies for colorectal cancer (CRC) are often limited by recurrence and resistance to drugs. Ferroptosis, a recently characterized form of programmed cell death, represents a promising avenue for CRC treatment. Speckle-type POZ protein (SPOP), a substrate receptor of the E3 ubiquitin ligase complex CRL3, has a crucial biological role, yet its function in CRC therapy and ability to regulate ferroptosis remain largely unexplored. In this study, we demonstrate that SPOP acts as a tum
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Written by Sarah Louise Bennett
Published in Vol 1 Issue 1, 2021
Despite the clinical success of immune checkpoint inhibitors (ICIs) in bladder cancer (BLCA), many patients fail to respond due to primary resistance. Neutrophil extracellular traps (NETs) have recently emerged as critical mediators of tumor therapy resistance, yet their precise function in BLCA is still unclear. We combined data from multiple ICI-treated patient cohorts to investigate the association between NET levels and clinical outcomes. Experimental approaches—including immunofluorescence,
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Written by Marco Antonio Bianchi
Published in Vol 1 Issue 1, 2021
Although immune checkpoint inhibitors (ICIs) have emerged as a transformative approach in cancer immunotherapy, their clinical benefit in colorectal cancer (CRC) remains modest. Elucidating the mechanisms that underlie resistance to ICIs in CRC is critical for identifying novel therapeutic targets. To dissect the role of CCL7 in CRC, we employed myeloid-specific Ccl7 knockout mice alongside MC38 tumor-bearing models. Tumor tissues were analyzed using proteomics, RNA sequencing, and flow cytometr
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Written by Ahmed Youssef El Sayed
Published in Vol 1 Issue 1, 2021
Gastric cancer (GC) continues to rank among the primary causes of cancer-associated deaths worldwide, with few effective treatments available and incompletely elucidated molecular pathways. By conducting comprehensive analyses of TCGA and GEO databases, along with validation in clinical samples, we detected recurrent elevated expression of the transcription factor PHOX1 in GC specimens. This upregulation was strongly linked to higher T/M stages and unfavorable patient outcomes. We established th
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