Eczema, a common non-communicable skin disorder, has been a long-standing concern. Current treatment protocols primarily focus on the skin itself, often relying on corticosteroids and other palliative drugs that can lead to significant side effects. Traditional Chinese Medicine (TCM) offers an alternative approach by addressing the underlying liver-skin axis. This case report describes the successful treatment of an 11-year-old girl with chronic eczema using TCM, specifically through liver clearing and detoxification. The patient was treated with the well-known TCM formula, long dan xie gan tang, which resulted in significant improvement and even complete resolution of eczema. Our clinical findings are consistent with those of the Chinese Society and provide new insights into the potential of liver detoxification and heat reduction in the treatment of eczema. This new approach to the liver-skin relationship may provide an effective strategy for managing eczema in patients.