Chronic illness in a child affects all aspects of family life and affects all family members. This study aimed to investigate the effectiveness of acceptance and commitment therapy (ACT) on the life satisfaction of mothers of children with cancer. The study included mothers of children with cancer, with a total of 32 participants selected through convenient sampling. These participants were randomly divided into 2 groups: an experimental group (16 mothers) and a control group (16 mothers). The Denier survey was used to assess life satisfaction. The data were analyzed using SPSS version 21 software. The results showed that ACT significantly improved life satisfaction among mothers of children with cancer. The effect size indicated that the significant improvement in life satisfaction could be attributed to acceptance and commitment-based therapy. Based on these findings, it can be concluded that acceptance and commitment therapy play a vital role in increasing life satisfaction by helping mothers to accept unavoidable negative emotions.
