Cancer remains a major global public health challenge and is among the leading causes of disease burden in various countries. This study aimed to examine the relationship between key factors such as screening, awareness, and beliefs about cancer, a critical health issue. Data from the Health Information National Trends Survey (HINTS 6) were used to analyze responses from 6,252 American adults. Pearson correlation coefficient (r) was used to assess the association between cancer screening, awareness, and beliefs. The findings indicated moderate to strong correlations between these variables. A significant positive correlation was observed between concern about developing cancer and interest in screening (r = 0.707; P < 0.001), as well as between cancer prevention and factors such as treatment, screenings (r = 0.608; P < 0.001), and general health status (r = 0.491; P < 0.001). It is believed that increased screening programs and awareness initiatives have a beneficial effect on individual health behaviors. Consequently, developing effective strategies to promote cancer awareness and screening could contribute to substantial advances in public health and cancer prevention efforts.