Volume 5, Issue 2 (2025)

The present study assessed whether cranberry supplementation influences liver enzyme activity, hepatic fat content, and cardiometabolic risk parameters in patients diagnosed with non-alcoholic fatty liver disease (NAFLD). This randomized, parallel-group clinical trial included 110 individuals diagnosed with NAFLD, who were assigned to either a 144 mg cranberry supplement or a placebo for a duration of six months. The study primarily evaluated effects on liver enzymes, glycemic control, and lipid

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Collaboration across countries is a cornerstone of global health research and delivery. One Retinoblastoma World (1RBW) functions as an international consortium of treatment centers providing care to children diagnosed with retinoblastoma. This study sought to quantify collaborative linkages within 1RBW, characterize their scope and form, and examine perceptions of their role in improving retinoblastoma outcomes. A cross-sectional egocentric network study using mixed methods was undertaken. All

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Depression is primarily characterized by emotional dysfunction, reflected in heightened negative emotions and diminished positive emotions. Consequently, accurate emotion recognition has become a crucial approach for assessing depression. Among the various signals employed for emotion recognition, electroencephalogram (EEG) signals have gained considerable attention due to their rich spatiotemporal information across multiple channels. In this study, EEG data were first preprocessed using filter

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Emerging evidence suggests that smartphone applications could support smokers in quitting. This study employed a single-group cohort design to assess both the practicality and user acceptance of a novel mobile app developed for smoking cessation in China, while also examining its effect on smoking quit rates. This study recruited 180 smokers from two mainland Chinese cities who were willing to attempt quitting. Participants engaged with a cognitive behavioral therapy (CBT)-based smoking cessatio

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Hypertension represents the most important modifiable contributor to cardiovascular morbidity and mortality worldwide. Persistent failures in identifying, treating, and controlling elevated blood pressure reflect missed opportunities to reduce avoidable deaths. This study sought to quantify the prevalence of long-term undiagnosed, untreated, and uncontrolled hypertension among older adults in Mexico, to examine their socioeconomic distribution, and to estimate the likelihood of transitioning fro

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In Mali, malaria exhibits strong seasonality, posing significant health risks to young children. To reduce this burden, Seasonal Malaria Chemoprevention (SMC) has been introduced, which entails providing monthly doses of antimalarial medication to children aged 3–59 months over a four-month period coinciding with peak malaria transmission. This study investigated changes in malaria incidence in the general population across the health districts of Kadiolo, Kati, Yorosso, Sikasso, and Tominian du

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The positive impacts of physical activity (PA) on children's health and overall well-being are widely recognized. Nevertheless, a significant number of children fail to achieve the recommended PA levels, heightening their susceptibility to overweight, obesity, and non-communicable diseases. Features of the home and neighborhood environments may limit opportunities for children to participate in PA, yet context-specific evidence is required to develop targeted interventions in underrepresente

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N6-methyladenosine (m6A) represents the most prevalent and dynamic post-transcriptional alteration on messenger RNAs in eukaryotic organisms, exerting a critical influence on the initiation and advancement of breast cancer (BC). Circular RNAs (circRNAs) have the capacity to function as oncogenic drivers or inhibitors through their role as microRNA (miRNA) decoys in BC. Nevertheless, the precise pathways by which circRNAs contribute to BC development by modulating m6A regulators are not fully elu

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Treatment options for rifampicin-resistant tuberculosis (RR-TB) remain limited, with existing regimens frequently prolonged and associated with poor tolerability. In light of emerging data from the TB-PRACTECAL trial, nations are evaluating the programmatic implementation of 6-month, fully oral regimens. A Markov model was employed to assess the incremental cost-effectiveness of three bedaquiline-, pretomanid-, and linezolid-based regimens (BPaL, with or without moxifloxacin [BPaLM] or clofazimi

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Given the extensive folkloric use of Mucuna pruriens (L.), the present work focuses on assessing the hepatoprotective and nephroprotective efficacy of its leaf extract, with the objective of determining its therapeutic relevance in the management of kidney and liver disorders. A total of forty male albino rats were used in this experiment and randomly distributed into eight groups, each consisting of five animals. The control group (Group I) received distilled water only. Hepatotoxicity and neph

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During the COVID-19 pandemic, personal protective measures such as face masks are considered crucial for reducing infection risk among both the healthcare workers and general population (HCWs), provided they are used correctly. This study aimed to evaluate whether Polish HCWs follow the 2020 World Health Organization (WHO) guidelines for proper mask use. A cross-sectional survey was conducted, with 1,156 participants responding to an online questionnaire assessing mask-related behaviors. Only 1.

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