Port-site metastasis after laparoscopic cholecystectomy in patients with gallbladder adenocarcinoma is an uncommon but serious concern in oncology. This disease is often challenging because of its delayed onset and the subsequent impact on prognosis. In this case, a 42-year-old woman developed a metastasis at the epigastric port site, 6 years following her laparoscopic cholecystectomy for gallbladder adenocarcinoma. The metastasis appeared as an ulcerative mass with features of squamous differentiation, and histopathological examination confirmed a poorly differentiated carcinoma. Notably, the patient had not sought follow-up care for cancer evaluation or undergone adjuvant therapy post-surgery, which contributed to this delayed complication. The case highlights the diagnostic difficulties posed by port-site metastasis and stresses the need for long-term surveillance in patients who have undergone gallbladder cancer treatment. Furthermore, this case underlines the importance of considering cutaneous malignancies in the differential diagnosis and addressing the surgical complexities of managing these metastases. Given the location of the mass near the subcostal margin and the risk of infection, the mesh could not be used during surgical excision, which complicated the procedure. This situation also increased the likelihood of an incisional hernia, necessitating further surgical intervention. The findings emphasize the critical role of consistent follow-up after laparoscopic cholecystectomy for gallbladder adenocarcinoma and the surgical challenges of achieving adequate margins, minimizing recurrence at port sites, and managing complications such as incisional hernias.
