Written by Ferran Pardo-Zamora
Published in Vol 4 Issue 1, 2024
Oral cancer, which originates in the oral cavity tissues, ranks as the eighth most common cancer globally, contributing to high mortality rates due to its often late detection. Although tissue biopsy remains the conventional method for diagnosis, it is invasive. Recently, liquid biopsy has emerged as a non-invasive diagnostic alternative. This method evaluates the tumor and its surrounding microenvironment by analyzing biomarkers found in bodily fluids such as blood, saliva, urine, and breast mi
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Written by Srivarsha Ranjeet
Published in Vol 4 Issue 1, 2024
Oral squamous cell carcinoma (OSCC), responsible for the vast majority of head and neck cancers (90–96%), remains a major global health concern. Molecular-level insight into this disease is critical for developing targeted therapies and enhancing patient care. This study explores the potential of Gymnema sylvestre (G. sylvestre), a natural compound, as an alternative anticoagulant to ethylenediaminetetraacetic acid (EDTA) for preserving blood samples intended for circulating tumor DNA (ctDNA) ex
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Written by Arnold A Mtenga
Published in Vol 4 Issue 1, 2024
The development of cancer during pregnancy is an uncommon occurrence. While breast and cervical cancers are more commonly reported in pregnant individuals, malignancies affecting the head and neck region—such as osteosarcoma—are particularly rare. Osteosarcoma of the jaw is exceptionally unusual during pregnancy and presents significant diagnostic difficulties. When diagnosed during gestation, this condition can adversely affect both maternal and fetal outcomes. This case report presents a 29-ye
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Written by Michał Miciak
Published in Vol 4 Issue 1, 2024
Medullary thyroid carcinoma (MTC) is an uncommon neuroendocrine tumor that originates from the parafollicular C cells in the thyroid. Unlike the more common papillary carcinoma, MTC tends to progress more aggressively and is prone to metastasis that is often unresponsive to chemotherapy. The main therapeutic approaches for MTC include surgical intervention and pharmacological treatments. Recent years have seen significant progress, particularly in the pharmacological management of MTC. This revi
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Written by Ling Xu
Published in Vol 4 Issue 1, 2024
Gastric cancer (GC) remains one of the most prevalent and fatal cancers worldwide, with high rates of both incidence and mortality. Unfortunately, most patients are diagnosed at advanced stages, often through routine screenings, missing the best time for intervention. In this research, weighted gene co-expression network analysis (WGCNA) was used to identify key gene modules and hub genes associated with GC. Using the “limma” package in R, differentially expressed genes (DEGs) were examined from
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Written by Delia Nica-Badea
Published in Vol 4 Issue 1, 2024
Human papillomaviruses (HPVs) are a family of small, DNA-based viruses that can cause either benign conditions or contribute to the development of cancerous tumors in humans. Some of the oncogenic strains, as supported by existing research, primarily infect epithelial cells and can be found in various areas of the skin and mucous membranes, including the genital, anal, oral, and respiratory tracts. Persistent HPV infection is a major risk factor for the development of numerous malignant tumors i
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