Written by Ashleigh C. Hamilton
Published in Vol 2 Issue 2, 2022
This study investigated the clinical and pathological profiles of germinal center (GC)-derived diffuse large B-cell lymphomas (DLBCL) with abnormal MUM1 co-expression, focusing on comparisons between pediatric and adult patients. A total of 32 cases showing aberrant MUM1 expression were analyzed, comprising 12 pediatric and 20 adult patients. The lymphomas showed a wide age distribution, affected various anatomical locations, and presented with complex histological and clinical features. Pediatr
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Written by Kerry J. Savage
Published in Vol 2 Issue 2, 2022
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is an uncommon form of Hodgkin lymphoma (HL) that is characterized by its distinct morphology, typically affects older individuals, and has a lower incidence of mediastinal involvement. It is also associated with a higher relapse rate and a better prognosis compared to classical Hodgkin lymphoma (CHL). Unlike CHL, the tumor cells in NLPHL, known as LP cells, usually retain a B cell phenotype and do not express CD30. Due to the rarity of thi
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Written by Prita Pradhan
Published in Vol 2 Issue 2, 2022
Dedifferentiated liposarcoma (DDL) with unusual forms of tissue differentiation is rarely seen and varies in presentation. These tumors often arise in the retroperitoneal area, where they tend to grow silently to a large size, appear late, and have a poor prognosis. We describe a rare case of an elderly male who initially presented with what appeared to be an inguinal hernia. Further evaluation revealed a large abdominal mass. CT imaging showed that the tumor occupied most of the left side of th
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Written by Francescamaria Donati
Published in Vol 2 Issue 2, 2022
The solid pseudopapillary tumor of the pancreas (SPT), also known as a Frantz tumor, was first identified in 1959 by its namesake. This uncommon pancreatic tumor, previously known as papillary epithelial neoplasm, low-grade papillary neoplasm, or solid and papillary neoplasm, predominantly affects younger individuals, with a notable female predominance. Its cellular origin remains uncertain, with potential links to acinar, endocrine, ductal, or progenitor cells. Characterized by a favorable prog
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Written by Marcela RosasNexticapa
Published in Vol 2 Issue 2, 2022
Prostate cancer remains one of the most common causes of cancer-related mortality among men globally. Evidence indicates that ribosomal S6 p90 kinases (RSK 1–4), a group of highly conserved serine/threonine kinases, may be associated with elevated prostate cancer levels. This study aimed to theoretically evaluate the interaction between various quinolone derivatives (compounds 1–19) and RSK-4, utilizing the structure of the 6rv2 protein and the known RSK-14 inhibitor, LJH685, through molecular d
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Written by Ana Tarhan
Published in Vol 2 Issue 2, 2022
Chemotherapy plays a central role in the management of advanced-stage gastric cancer, helping to extend survival and improve quality of life. However, there is still no consensus on whether doublet or triplet chemotherapy regimens should be used as the standard treatment for these patients. This retrospective study examines first-line chemotherapy options for metastatic gastric cancer at five medical centers in Turkey. The inclusion criteria required patients to have metastatic gastric adenocarc
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Written by Gaurav Singh
Published in Vol 2 Issue 2, 2022
Early diagnosis and prompt treatment of pediatric acute leukemia are crucial for improving survival outcomes. This study aimed to investigate the factors contributing to delays in diagnosing acute leukemia in children. A prospective observational study was conducted at a specialized hospital in Northern India, enrolling 100 children aged 0-12 years over 18 months. A combination of quantitative data and qualitative interviews was used to gather insights. Caregivers completed a standardized questi
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