Written by Fabrizio Fabrizi
Published in Vol 1 Issue 1, 2021
The global impact of the COVID-19 pandemic has been widespread, and acute kidney injury (AKI) is a significant risk among individuals infected with SARS-CoV-2. This systematic review combines the findings of several systematic reviews on the incidence of AKI in COVID-19 patients. The review adhered to the PRISMA guidelines and conducted an extensive search of databases, including OVID, the Cochrane Library, EMBASE, ProQuest, PubMed, ScienceDirect, Scopus, and Web of Science until March 17, 2021.
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Written by Mariia Sergeevna Soboleva
Published in Vol 1 Issue 1, 2021
The available data on previous distant learning models and interactive methods in the field of “Pharmacy,” detailing their features, pros, and cons, are limited. This study aims to examine the components of different educational methods used at the Far Eastern State Medical University. A survey was conducted among 267 students enrolled in the “Pharmacy” program at the Faculty of Pharmacy and Biomedicine (higher education) and the Medico-Pharmaceutical College (secondary education). Key advantage
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Written by Phuong Dong Tran Nguyen
Published in Vol 1 Issue 1, 2021
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a crucial enzyme involved in the regulation of circulating low-density lipoprotein cholesterol (LDL-C). Variations in the PCSK9 gene can have significant effects on LDL receptor degradation—gain-of-function mutations accelerate receptor breakdown and contribute to familial hypercholesterolemia (FH), while loss-of-function mutations increase receptor availability, lower LDL-C levels, and reduce the risk of coronary heart disease. The geneti
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Written by Tao Zeng
Published in Vol 1 Issue 1, 2021
Eczema, a common non-communicable skin disorder, has been a long-standing concern. Current treatment protocols primarily focus on the skin itself, often relying on corticosteroids and other palliative drugs that can lead to significant side effects. Traditional Chinese Medicine (TCM) offers an alternative approach by addressing the underlying liver-skin axis. This case report describes the successful treatment of an 11-year-old girl with chronic eczema using TCM, specifically through liver clear
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Written by Refat M. Hassan
Published in Vol 1 Issue 1, 2021
The present study aimed at developing a new keto acid precursor for the oxidation of lambda-carrageenan via alkaline permanganate. A new class of keto-acid derivatives of lambda-carrageenan (LCAR), in the form of sulfated polysaccharides, was synthesized by oxidizing LCAR with permanganate ions in an alkaline environment at pH levels greater than 12. The reactants MnO4-, LCAR, and NaF were combined in precise stoichiometric ratios in alkaline solutions with pH values above 12. The mixture was st
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Written by Filippo Confalonieri
Published in Vol 1 Issue 1, 2021
Retinal vessels are vulnerable to damage from a variety of factors, including retinal tears, retinal detachment, sickle cell disease, macular degeneration, aneurysms, trauma, and venous occlusion, which can lead to retinal bleeding, commonly referred to as vitreous hemorrhage. This review highlights the advances made in the treatment of vitreous hemorrhage. This review was based on articles selected from the PubMed database, using the following key terms: diagnosis, vitreous hemorrhage, risk fac
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Written by Petro Bodnar
Published in Vol 1 Issue 1, 2021
A frequent complication observed in cancer patients is thrombosis, which affects both arterial and venous circulation. However, the exact mechanisms of blood clot formation and the development of disseminated intravascular coagulation (DIC) remain unclear. This study performed a morpho-histological examination of the lower limb muscles in two groups of cancer patients who also experienced deep vein thrombosis leading to thrombus migration. In both groups, which succumbed to pulmonary embolism fo
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Written by David Matthew Clark
Published in Vol 1 Issue 1, 2021
Exposure to violent media during early childhood represents a modifiable risk factor for preventive interventions. While prior research has documented links between violent media exposure and aggressive tendencies in childhood, few studies have examined the enduring associations with antisocial behavior into adolescence. This study explores prospective links between early exposure to violent television and later antisocial outcomes in mid-adolescence. The sample comprised 963 girls and 982 boys
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Written by Anna Katarina Lundqvist
Published in Vol 1 Issue 1, 2021
Ischemic stroke (IS) represents a major global health burden and remains a leading cause of disability and mortality, underscoring the urgent need for improved therapeutic strategies. Tianjiangxueshuantong (TJXST) pills are widely prescribed for cerebrovascular disorders and include ginseng as a key herbal constituent; however, the specific contribution and mechanistic role of ginseng in IS therapy have not been comprehensively clarified. The present study aims to systematically evaluate the pro
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Written by Patrick Andrew Oconnor
Published in Vol 1 Issue 1, 2021
Osteoporosis represents a major global health challenge. Cyclolinopeptides (CLPs), which are cyclic hydrophobic peptides derived from flaxseed oil, exhibit antioxidative, immunomodulatory, and antiosteoporotic activities; however, their therapeutic utility in osteoporosis remains insufficiently studied. This study aimed to explore the potential protective effects of CLP-A, CLP-E, and CLP-P in the context of osteoporosis using in vitro models.Potential overlapping targets of CLP-A, CLP-E, and CLP
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Written by Alexander Paul Stevens
Published in Vol 1 Issue 1, 2021
The prevalence of tooth loss in indigenous communities of the Amazon highlights the urgency of implementing oral health strategies that respect cultural contexts. This study aimed to determine the rate of tooth loss over a 13-year span in two remote indigenous populations. A prospective cohort followed 47 individuals with permanent dentition at baseline (T0) and 13 years later (T1) from the villages of Arara-Laranjal (n = 28; mean ages 16.1 and 29.9 years) and Assurini do Xingu (n = 19; mean age
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Written by Hannah Louise Cooper
Published in Vol 1 Issue 1, 2021
This in-depth review explores the contribution of acarbose to blood glucose regulation, with a focus on its application in type 1 diabetes, type 2 diabetes mellitus (T2DM), and gestational diabetes mellitus (GDM). As an alpha-glucosidase inhibitor, acarbose functions by slowing the breakdown of carbohydrates in the small intestine, thus avoiding abrupt rises in blood glucose after meals. This mode of action plays an essential role in achieving steady glucose levels and lowering HbA1c, which help
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Written by Elena Martina Ferrari
Published in Vol 1 Issue 1, 2021
Sick leave among healthcare workers (HCWs) can disrupt hospital operations and negatively affect patient care quality. This study aimed to explore the factors associated with absenteeism due to sickness among HCWs in a tertiary hospital in Lebanon. A retrospective review of sick leave records and corresponding health data was conducted for 2,850 HCWs from 2015 to 2018. Sick leave events were classified by diagnostic categories. Associations between demographic, occupational, and health-related f
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Written by Thomas Edward Wilson
Published in Vol 1 Issue 1, 2021
This study aimed to investigate whether the Triglyceride-Glucose (TyG) index and its derived measures—TyG-BMI, TyG-WC, and TyG-WHtR—are linked to non-suicidal self-injury (NSSI) in adolescents diagnosed with Major Depressive Disorder (MDD), and to assess whether sleep quality serves as an intermediary factor in these associations. A total of 157 adolescents aged 12–18 years, all diagnosed with MDD, were enrolled from the Department of Mental Health at the Second Hospital of Lanzhou University be
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Written by Peter Nathan Caldwell
Published in Vol 1 Issue 1, 2021
Sleep disturbances have become a significant issue among adolescents and young adults in China after the relaxation of COVID-19 control measures. This research sought to examine the occurrence rate, contributing elements, and connections to psychological well-being related to sleep difficulties in student populations during this transition phase. An online-based cross-sectional study involved 82,873 participants from educational institutions in Sichuan Province, China, utilizing a custom questio
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Written by Katarina Milena Petrovic
Published in Vol 1 Issue 1, 2021
Schizophrenia represents a chronic and debilitating mental disorder that significantly affects patients’ daily functioning and creates societal challenges. Long-acting injectable antipsychotics (LAIs) have been shown to enhance adherence and lower relapse and hospitalization rates compared with oral antipsychotic treatments, yet their adoption differs widely between countries. The qualitative portion of the global ADVANCE study (Attitudes DriVing regional differences in long-acting injectable AN
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Written by Luis Fernando Morales
Published in Vol 1 Issue 1, 2021
Post-acute sequelae of COVID-19 (PASC), widely known as “long COVID,” is a persistent, debilitating condition without established treatments that substantially affects quality of life. Qigong, a practice rooted in Traditional Chinese Medicine (TCM), may offer a novel therapeutic option for PASC. This study aimed to understand participants’ subjective experiences of qi and any perceived changes in PASC symptoms following participation in a clinical trial that combined group-based internal and ext
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Written by Maria Alessandra Ricci
Published in Vol 1 Issue 1, 2021
Alterations of the cerebral cortex are a well-documented feature of schizophrenia spectrum disorders (SSD), with frontal and temporal regions being particularly affected. Despite this, the majority of prior neuroimaging research has emphasized macrostructural characteristics—such as cortical thickness, volume, and surface area—rather than properties at the tissue microstructural level. Quantitative T1 (qT1) imaging enables in vivo assessment of cortical microstructure and is thought to predomina
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Written by Nicolas Jean Dupont
Published in Vol 1 Issue 1, 2021
Traditional evaluation instruments often fall short in capturing the effects of localized interventions, such as community meal programs or farmers’ markets, on fruit and vegetable intake. This study presents pilot findings from a newly developed tool designed to measure the impact of community-based programs on dietary behaviors, specifically addressing the lack of effective evaluation methods in underserved populations. Using a participatory research framework, the survey was co-designed with
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