Written by Leonidas Palaiodimos
Published in Vol 2 Issue 1, 2022
Obesity has now become a global concern and contributes to various risk factors, especially in Western countries, where its prevalence has increased sharply. This surge has led to a significant increase in cardiovascular diseases in the general population. Inflammatory proteins, such as C-reactive protein (CRP), play an important role in the acute phase response to inflammation. This study aimed to investigate the impact of obesity on inflammation, as measured by CRP levels, in obese patients wh
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Written by Lutsak Iryna
Published in Vol 2 Issue 1, 2022
This article aims to highlight the treatment of respiratory diseases during the COVID-19 pandemic, with a focus on vaccination and the impact of the disease on children. The study uses a longitudinal design, referencing English-language resources such as UpToDate, peer-reviewed journals, and surveys from outpatient healthcare practitioners. While there were no major changes to the treatment of respiratory diseases during the pandemic, there were updates to the recommendations for aerosolized dru
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Written by Abdelrahman Mohamed Ahmed Abukanna
Published in Vol 2 Issue 1, 2022
Medical students are often considered a high-risk group for stress-related conditions, including primary headaches. Previous research on primary headaches in this population has shown an association between poor academic performance and the need for intervention. This study aimed to assess the prevalence of primary headaches among medical students at Northern Border University in Arar, Saudi Arabia. This cross-sectional study used an online questionnaire administered at a single point in time. T
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Written by Li Guo
Published in Vol 2 Issue 1, 2022
Traditional Chinese Medicine Constitution (TCMC) provides valuable insights into an individual’s physical, mental, and overall health profile. Gaining a deeper understanding of TCMC types and their influencing factors may help promote health and prevent disease. While previous cross-sectional studies have identified common characteristics of TCMC and their associated factors, there remains a lack of longitudinal research tracking these changes over time. This follow-up study aimed to investigate
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Written by Anna Dziewulska
Published in Vol 2 Issue 1, 2022
The identification of the gingival phenotype and its relationship to periodontal health is essential for providing effective treatment. This study investigated the prevalence of different gingival phenotypes and how they relate to various factors such as crown shape, papilla height (PH), keratinized tissue width (KTW), and other potential risk factors. A total of 90 participants, including 53 women and 37 men, participated in the study. The gingival phenotype was classified as thin or thick base
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Written by Hafsah Saeed
Published in Vol 2 Issue 1, 2022
According to projections from the W.H.O., ischemic heart disease was expected to emerge as the leading global cause of illness by 2020, closely followed by major depressive disorders as the second most important cause. The future landscape of global health will likely be shaped by the complex interplay between cardiovascular disease and psychiatric conditions. There is a strong association between an individual’s mental health and their lifestyle choices, both of which can significantly influenc
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Written by Paula Veronica Mendes
Published in Vol 2 Issue 1, 2022
Melaleuca leucadendron, commonly referred to as Eucalyptus, has been extensively applied in folk remedies and modern therapeutics because of its wide-ranging bioactive effects. This species is rich in various natural compounds that account for its capabilities in reducing inflammation, alleviating pain, regulating blood glucose, and combating cancer cells. The objective of this research was to investigate the antimicrobial effects of extracts obtained from M. leucadendron leaves on microorganism
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Written by Laura Beatrice Conti
Published in Vol 2 Issue 1, 2022
Endometriosis (EM) represents a persistent inflammatory condition marked by the presence of endometrium-like tissue outside its normal location and associated fibrotic changes. Alterations in metabolism, notably heightened glycolytic processes, along with disruptions in the immune milieu, constitute prominent aspects of EM advancement. Nonetheless, the precise molecular pathways involved are still inadequately clarified. The present investigation employed a combination of transcriptome profiling
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Written by Mohamed Ibrahim Hassan
Published in Vol 2 Issue 1, 2022
Occult hepatitis B virus infection (OBI) is associated with substantial risks of transmission and disease progression. Alterations in the S gene are regarded as key factors in the emergence of OBI. A prior investigation by our group detected the C138R substitution in the S gene among individuals with OBI. The present work sought to examine the influence of the C138R substitution on HBsAg functionality and the underlying processes responsible for OBI. Complete HBV genome constructs (HBV 1.3, geno
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Written by Yuki Haruto Tanaka
Published in Vol 2 Issue 1, 2022
Non-small cell lung cancer (NSCLC) involves aberrant epidermal growth factor receptor (EGFR) activation resulting from overexpression or mutations. Although EGFR tyrosine kinase inhibitors (TKIs) like gefitinib are employed in NSCLC therapy, resistance frequently emerges through secondary EGFR mutations or bypass signaling pathways. Thus, new agents capable of bypassing EGFR-TKI resistance are essential for improved NSCLC management. Narciclasine (Ncs) is a cytotoxic alkaloid derived from Narcis
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Written by Daniel Victor Alvarez
Published in Vol 2 Issue 1, 2022
Migrasomes represent an emerging category of extracellular vesicles, but their contribution to metastasis in colorectal cancer (CRC) is not well elucidated. The present research sought to examine the role of migrasomes originating from CRC cells, especially in low-oxygen environments, in driving spread to the liver and altering the immune landscape within tumors.The presence of migrasomes in CRC samples and cell lines was assessed through transmission electron microscopy and immunofluorescence t
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Written by Markus Daniel Hofmann
Published in Vol 2 Issue 1, 2022
This paper offers a detailed examination of the morphological, micromorphological, and phytochemical profiles of two Tribulus species found in Vietnam: Tribulus cistoides L. and Tribulus terrestris L. The research seeks to outline and contrast the morphological and anatomical traits, together with the phytochemical content in the stems and leaves of these species, to explore their possible uses in pharmaceuticals. This was achieved through the double-staining technique and initial phytochemical
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Written by Natalie Rose Bennett
Published in Vol 2 Issue 1, 2022
Numerous approaches targeting the CXCL12 pathway, particularly CXCR4 inhibitors, have been explored for treating colorectal cancer (CRC). Although these methods have demonstrated partial success in clinical studies, the reasons why reduced CXCL12 levels impair the effectiveness of anti-PD-L1 therapy—a major obstacle in immunotherapy—remain poorly understood, underscoring the necessity for further mechanistic investigation and improved therapeutic approaches. This research combined single-cell tr
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