Due to the widespread nature of breast cancer and its significant impact on the quality of life for those affected, this study aimed to evaluate how palliative care education affects the quality of life of women with breast cancer. In this clinical trial, 46 breast cancer patients were randomly assigned to either an intervention group or a control group. While the control group received standard care, the intervention group participated in 4 weeks of specialized palliative care training. The Missoula quality of life questionnaire was administered to both groups before, immediately after, and one month following the intervention. Data analysis was performed using independent t-tests, paired t-tests, and chi-square tests through SPSS version 23 software. The results showed a significant improvement in the quality of life scores of the intervention group before and after the training (P = 0.003), while no significant change was observed in the control group (P = 0.67). In addition, there was a significant difference in the quality of life scores between the two groups both immediately and one month after the intervention (P < 0.0001). These findings suggest that palliative care education can significantly improve the quality of life for breast cancer patients, advocating for the widespread integration of such care through patient-centered training.